Biological collections for health and longevity: trends in the plant genetic resources utilization
https://doi.org/10.30901/2658-6266-2026-1-o1
Abstract
The study of genetic resource collections has led to the development of modern biotechnology methods. Today, with the accumulation of big data in genomics and omics, biological collections are of paramount importance for the development of personalized approaches in medicine and nutrition. Interdisciplinary comprehensive research in the field of healthy nutrition, based on classical nutrition and dietetics, now encompasses human nutriogenomics using omics approaches, nutritional and nutriogenomic experiments on model animals, nutritional phenotyping of plant genetic resources along with their biochemical and metabolomic analysis, and science-intensive methods for processing plant materials. It is emphasized that such an integrated approach not only forms the basis for important developments in personalized nutrition but also opens the door to personalized plant breeding for the human diet. Emphasis is placed on the study of the genetic resources of cultivated plants with geroprotective properties and the importance of biofortification of plant varieties used in the production of everyday foods.
Keywords
Supporting agencies: The article was prepared within the framework of research topic No. 0481-2022-0007.
About the Author
E. K. Khlestkina
N.I. Vavilov All-Russian Institute of Plant Genetic Resources; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elena K. Khlestkina, Dr. Sci. (Biology), Corr. Member of the Russian Academy of Sciences, Director, VIR; ICG SB RAS
42, 44, Bolshaya Morskaya Street, St. Petersburg, 190000 Russia; 10, Academician Lavrentyev Avenue, Novosibirsk, 630090 Russia
References
1. Agureev A.N., Pavlova L.P., Makarov V.N., Akimov M.Yu., Vlazneva L.N., Koltsov V.A. Assessment of the nutritional status of cosmonauts on diets containing Michurin products (Otsenka pishchevogo statusa kosmonavtov pri pitanii ratsionami s vklyucheniyem v ikh sostav michurinskikh produktov). In: Scientific and practical foundations for accelerating import substitution of horticultural products: Proceedings of the scientific and practical conference (Nauchno-prakticheskiye osnovy uskoreniya importozameshcheniya produktsii sadovodstva: materialy nauchno-prakticheskoy konferentsii); 2016 September 7-9, Michurinsk-Science City, Russia. Michurinsk-Science City; 2017. p. 29-33. [in Russian]
2. Badaeva A.V., Danilov A.B., Clayton P., Moskalev A.A., Karasev A.V., Tarasevich A.F., Vorobyeva Y.D., Novikov V.N. Perspectives on neuronutrition in prevention and treatment of neurological disorders. Nutrients. 2023;15(11):2505. DOI: 10.3390/nu15112505
3. Chien A., Edgar D.B., Trela J.M. Deoxyribonucleic acid polymerase from the extreme thermophile Thermus aquaticus. Journal of Bacteriology. 1976;127(3):1550-1557. DOI: 10.1128/jb.127.3.1550-1557.1976
4. Drozd E.V., Babak O.G., Nekrashevich N.A., Anisimova N.V., Nikitinskaya T.V., Yatsevich K.K., Gashkova I.V., Artemyeva A.M., Kilchevsky A.V. Study of anthocyanin accumulation peculiarities in Solanum melongena depending on the polymorphism of activator-type R2R3-MYB genes. Molecular & Applied Genetics Proceedings. 2022;32:6-17. [in Russian]
5. Glotov A., Nasykhova Yu., Dvoynova N., Mikhailova A., Pachulia O., Danilova M., Tonyan Z., Barbitoff Yu., Illarionov R., Bespalova O., Baranov V., Kogan I. Prospects for biobanking in reproductive health: genetic aspects. Biological Communications. 2022;67(4):286-300. DOI: 10.21638/spbu03.2022.404
6. Gridina M.M., Nurislamov A.R., Minina J.M., Karamysheva T.V., Rubtsov N.B., Serov O.L., Lopatkina M.E., Drozdov G.V., Vasilyev S.A., Minaycheva L.I., Belyaeva E.O., Nikitina T.V., Kashevarova A.A., Lebedev I.N. Generation of iPS cell line (ICGi040-A) from skin fibroblasts of a patient with ring small supernumerary marker chromosome 4. Stem Cell Research. 2022;61:102740. DOI: 10.1016/j.scr.2022.102740
7. Jinek M., Chylinski K., Fonfara I., Hauer M., Doudna J.A., Charpentier E.A. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science. 2012;337(6096):816-821. DOI: 10.1126/science.1225829
8. Konarev A.V. Biochemistry of cultivated plants and the global collection of VIR in the context of healthy nutrition issues. Plant Biotechnology and Breeding. 2025;8(1):46-52. [in Russian]. DOI: 10.30901/2658-6266-2025-1-o4
9. Lukina K.A., Shoeva O.Y., Kovaleva O.N., Loskutov I.G. Anthocyanin content in grains of barley and oat accessions from the VIR collection. Plant Biotechnology and Breeding. 2021;4(3):5-14. [in Russian]. DOI: 10.30901/2658-6266-2021-3-o4
10. Makarov V.N., Vlazneva L.N., Akimov M.Yu. New fruit and vegetable functional products for school nutrition. Pediatric Nutrition. 2009;7(3):62-65. [in Russian]
11. Malysheva N.Yu., Shelenga T.V., Solovyeva A.E., Nagiev T.B., Kovaleva N.V., Malyshev L.L. Metabolomic approach to investigate Dactylis glomerata L. from the VIR collection. Vavilov Journal of Genetics and Breeding. 2023;27(2):111-118. DOI: 10.18699/VJGB-23-16
12. McClintock B. The origin and behavior of mutable loci in maize. Proceedings of the National Academy of Sciences of the United States of America. 1950;36(6):344-355. DOI: 10.1073/pnas.36.6.344
13. Meselson M., Yuan R. DNA restriction enzyme from E. coli. Nature. 1968;217(5134):1110-1104. DOI: 10.1038/2171110a0
14. Mikhailova A.A., Bogomiagkova E.S., Nasykhova Yu.A., Illarionov R.A., Danilova M.M., Tonyan Z.N., Chernykh V.B., Kovalenko L.V., Bespalova O.N., Glotov A.S. Healthcare professionals and scientists’ collaboration with biobanks: a pilot study on the assessment of knowledge and attitudes toward biospecimen donation. Frontiers in Medicine. 2025;12:1497209. DOI: 10.3389/fmed.2025.1497209
15. Mikhailova D.V., Shevchenko O.G., Golubev D.A., Platonova E.Y., Zemskaya N.V., Shoeva O.Y., Gordeeva E.I., Patov S.A., Shaposhnikov M.V., Khlestkina E.K., Moskalev A.A. Antioxidant properties and geroprotective potential of wheat bran extracts with increased content of anthocyanins. Antioxidants (Basel). 2023;12(11):2010. DOI: 10.3390/antiox12112010
16. Mikhailova D.V., Zemskaya N.V., Timusheva N.S., Pakshina N.R., Platonova E.Y., Koval L.A., Schegoleva E.V., Yakovleva D.V., Golubev D.A., Kurkiev K.U., Gadjimagomedova M.K., Khlestkina E.K., Shaposhnikov M.V., Moskalev A. Sex-specific effects of cereal-based diets on longevity and healthspan in Drosophila melanogaster. Biogerontology. 2026;27(2):49. DOI: 10.1007/s10522-026-10395-3
17. Napoli C., Lemieux C., Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell. 1990;2(4):279-289. DOI: 10.1105/tpc.2.4.279
18. Nikityuk D.B., Akimov M.Yu., Kharnikov M.V., Gryazev E.E. Establishment of a consulting and diagnostic center "Health and Sports Nutrition" in Michurinsk-Science City of the Russian Federation, Tambov Region (Sozdaniye konsul'tatsionno-diagnosticheskogo tsentra «Zdorov'ye i sportivnoye pitaniye» v Michurinsk-Naukograde RF Tambovskoy oblasti). In: Development of production and scientific potential of the horticulture and nursery industry in the Russian Federation: Proceedings of the scientific and practical conference (Razvitiye proizvodstvennogo i nauchnogo potentsiala otrasli sadovodstva i pitomnikovodstva v Rossiyskoy Federatsii: materialy nauchno-prakticheskoy konferentsii); 2019 September 12-14; Michurinsk, Russia. Michurinsk; 2019. p. 274-278. [in Russian]
19. Orlova S.Yu., Yushev A.A., Shelenga T.V. Chemical composition of bird cherry fruits in the Northwestern region of Russia. Proceedings on Applied Botany, Genetics and Breeding. 2020;181(2):65-72. [in Russian]. DOI: 10.30901/2227-8834-2020-2-65-72
20. Pachulia O.V., Illarionov R.A., Vashukova E.S., Postnikova T.B., Maltseva A.R., Popova A.K., Kornyushina E.A., Bespalova O.N., Glotov A.S. Strategies for bioresource collection in obstetrics: the experience of the “Genofund” biobank. Cardiovascular Therapy and Prevention. 2024;23(11):4193. [in Russian]. DOI: 10.15829/1728-8800-2024-4193
21. Piskunova T.M., Shelenga T.V., Ozersky P.V., Solovyeva A.E. Carotenoids and carotenes in the fruits of Cucurbita maxima, C. moschata and C. pepo under the conditions of Northwestern Russia. Proceedings on Applied Botany, Genetics and Breeding. 2023;184(1):118-127. DOI: 10.30901/2227-8834-2023-1-118-127
22. Shamanin V.P., Chursin A.S., Morgunov A.I., Shepelev S.S., Kuzmin O.G., Gladkikh M.S., Pozherukova V.E., Khlestkina E.K., Gordeeva E.I., Pototskaya I.V. ‘EF 22’ cultivar of common spring wheat (Triticum aestivum L.) (Sort «EF 22» pshenitsy myagkoy yarovoy (Triticum aestivum L.)). Russian Federation; Patent No. 13333; 2024). [in Russian]
23. Shelenga T.V., Kerv Y.A., Perchuk I.N., Solovyeva A.E., Khlestkina E.K., Loskutov I.G., Konarev A.V. The potential of small grains crops in enhancing biofortification breeding strategies for human health benefit. Agronomy. 2021;11(7):1420. DOI: 10.3390/agronomy11071420
24. Shelenga T.V., Popov V.S., Konarev A.V., Tikhonova N.G., Tikhonova O.A., Kerv Yu.A., Smolenskaya A.E., Malyshev L.L. Metabolomic profiles of Ribes nigrum L. and Lonicera caerulea L. from the collection of the N.I. Vavilov Institute in the setting of Northwest Russia. Vavilov Journal of Genetics and Breeding. 2022;26(7):630-636. DOI: 10.18699/VJGB-22-77
25. Smirnov A., Nurislamov A., Koncevaya G., Serova I., Kabirova E., Chuyko E., Maltceva E., Savoskin M., Zadorozhny D., Svyatchenko V.A., Protopopova E.V., Taranov O.S., Legostaev S.S., Loktev V.B., Serov O., Battulin N. Characterizing a lethal CAG-ACE2 transgenic mouse model for SARS-CoV-2 infection using Cas9-enhanced nanopore sequencing. Transgenic Research. 2024;33(5):453-466. DOI: 10.1007/s11248-024-00413-w
26. Solovyeva A.E., Shelenga T.V., Artemyeva A.M. The metabolomic approach to the complex biochemical characteristics of cole Brassica oleracea L. Vegetable crops of Russia. 2019;(4):72-79. [in Russian]. DOI: 10.18619/2072-9146-2019-4-72-79
27. Tikhonova M.A., Shoeva O.Yu., Tenditnik M.V., Ovsyukova M.V., Akopyan A.A., Dubrovina N.I., Amstislavskaya T.G., Khlestkina E.K. Evaluating the effects of grain of isogenic wheat lines differing in the content of anthocyanins in mouse models of neurodegenerative disorders. Nutrients. 2020a;12:3877. DOI: 10.3390/nu12123877
28. Tikhonova M.A., Shoeva O.Y., Tenditnik M.V., Akopyan A.A., Litvinova E.A., Popova N.A., Amstislavskaya T.G., Khlestkina E.K. Antitumor effects of an anthocyanin-rich grain diet in a mouse model of Lewis lung carcinoma. International Journal of Molecular Sciences. 2024;25(11):5727. DOI: 10.3390/ ijms25115727
29. Tikhonova M.A., Tikhonova N.G., Tenditnik M.V., Ovsyukova M.V., Akopyan A.A., Dubrovina N.I., Amstislavskaya T.G., Khlestkina E.K. Effects of grape polyphenols on the life span and neuroinflammatory alterations related to neurodegenerative Parkinson disease-like disturbances in mice. Molecules 2020b;25(22):5339. DOI: 10.3390/molecules25225339
30. Tikhonovich I.A., Geltman D.V., Chernetsov N.S., Mikhailova N.А., Glotov A.S., Khlestkin V.K., Ukhatova Y.V., Zavarzin А.A., Nizhnikov A.A., Khlestkina E.K. On the results of the First Scientific Forum «Genetic Resources of Russia»: prospects for development, research and practical potential of bio-collections. Plant Biotechnology and Breeding. 2022;5(2):38-47. [in Russian]. DOI: 10.30901/2658-6266-2022-2-o4
31. Tkachenko A.A., Changalidis A.I., Maksiutenko E.M., Nasykhova Yu.A., Barbitoff Yu.A., Glotov A.S. Replication of known and identification of novel associations in biobank-scale datasets: a survey using UK Biobank and FinnGen. Genes. 2024;15(7):931. DOI: 10.3390/genes15070931
32. Tutelyan V.A., Atkov O.Yu., Baranov V.M., Nikityuk D.B. (eds). Space nutritionology (Kosmicheskaya nutritsiologiya). Moscow: DeLi; 2025. [in Russian]
33. Tutelyan V.A., Nikityuk D.B., Kon I.Ya., Pyryeva E.A. (eds). Innovations in child food: annual publication with catalog (Innovatsii v detskom pitanii: yezhegodnoye izdaniye s katalogom). Issue 1. Moscow: Medical Information Agency (MIA); 2019. [in Russian]
34. Tutelyan V.A., Nikityuk D.B. (eds). Nutrition and clinical dietetics: national guidelines (Nutritsiologiya i klinicheskaya diyetologiya: natsional'noye rukovodstvo). 3rd edition revised and enlarged. Moscow: GEOTAR-Media; 2026. [in Russian]. DOI: 10.33029/9704-9592-6-NKD-2026-1-1040
35. van der Krol A.R., Mur L.A., Beld M., Mol J.N., Stuitje A.R. Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression. Plant Cell. 1990;2(4):291-299. DOI: 10.1105/tpc.2.4.291
36. Xiao X., Fu L., Zhang Z., Tu Z., Shen N., Fan S. Recent advances in integrating machine learning with omics approaches in food science and nutrition research. Journal of Agricultural and Food Chemistry. 2025;73(47):29998-30025. DOI: 10.1021/acs.jafc.5c08522
37. Zhang J., Hansen L.G., Gudich O., Viehrig K., Lassen L.M.M., Schrübbers L., Adhikari K.B., Rubaszka P., Carrasquer-Alvarez E., Chen L., D’Ambrosio V., Lehka B., Haidar A.K., Nallapareddy S., Giannakou K., Laloux M., Arsovska D., Jørgensen M.A.K., Chan L.J.G., Kristensen M., Christensen H.B., Sudarsan S., Stander E.A., Baidoo E., Petzold C.J., Wulff T., O’Connor S.E., Courdavault V., Jensen M.K., Keasling J.D. A microbial supply chain for production of the anti-cancer drug vinblastine. Nature. 2022;609(7926):341-347. DOI: 10.1038/s41586-022-05157-3
Review
For citations:
Khlestkina E.K. Biological collections for health and longevity: trends in the plant genetic resources utilization. Plant Biotechnology and Breeding. (In Russ.) https://doi.org/10.30901/2658-6266-2026-1-o1
Views:
55
JATS XML
Email this article 